2-METHOXYESTRADIOL
- Product Name
- 2-METHOXYESTRADIOL
- CAS No.
- 362-07-2
- Chemical Name
- 2-METHOXYESTRADIOL
- Synonyms
- 2-Methoxy 17β-Estradiol;2-ME2;Panzem;2-MeOE2;NSC 659853;Methoxy estradiol;7-Methoxyestradiol;2-METHOXYESTRADIOL;2-METHOXYOESTRADIOL;2-Methoxy-β-estradiol
- CBNumber
- CB5268052
- Molecular Formula
- C19H26O3
- Formula Weight
- 302.41
- MOL File
- 362-07-2.mol
2-METHOXYESTRADIOL Property
- Melting point:
- 188-190°C
- Boiling point:
- 464.4±45.0 °C(Predicted)
- Density
- 1.178±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO: 10 mg/mL
- form
- crystalline
- pka
- 10.29±0.60(Predicted)
- color
- light yellow
- λmax
- 286nm(EtOH)(lit.)
- InChIKey
- CQOQDQWUFQDJMK-SSTWWWIQSA-N
- CAS DataBase Reference
- 362-07-2(CAS DataBase Reference)
Safety
- Hazard Codes
- T,Xi,N
- Risk Statements
- 23/24/25-36/37/38-48-61-60-46-45-51/53
- Safety Statements
- 22-26-36/37/39-45-53-36-61
- RIDADR
- UN 3077 9/PG 3
- WGK Germany
- 3
- RTECS
- KG7537500
- HS Code
- 2937.23.5050
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H350May cause cancer
H360May damage fertility or the unborn child
H372Causes damage to organs through prolonged or repeated exposure
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 454180
- Product name
- 2-Methoxyestradiol
- Packaging
- 10mg
- Price
- $113
- Updated
- 2024/03/01
- Product number
- 454180
- Product name
- 2-Methoxyestradiol
- Packaging
- 50mg
- Price
- $417
- Updated
- 2024/03/01
- Product number
- M2530
- Product name
- 2-Methoxy-β-estradiol
- Purity
- >97.0%(GC)
- Packaging
- 25mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- M2530
- Product name
- 2-Methoxy-β-estradiol
- Purity
- >97.0%(GC)
- Packaging
- 100mg
- Price
- $117
- Updated
- 2024/03/01
- Product number
- 13021
- Product name
- 2-Methoxyestradiol
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $31
- Updated
- 2024/03/01
2-METHOXYESTRADIOL Chemical Properties,Usage,Production
Chemical Properties
Off-White Solid
Uses
A natural metabolite of 17?Estradiol which is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. Binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule a
Uses
A natural metabolite of 17β-Estradiol which is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. Binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule assembly
Uses
2-Methoxyestradiol is a tubulin polymerization inhibitor and also decreases HIF-1 activity.
Uses
2-Methoxyestradiol depolymerizes microtubules and blocks HIF-1α nuclear accumulation and HIF-transcriptional activity. Phase 2.
Uses
2-Methoxy 17β-Estradiol is a natural metabolite of 17β-Estradiol which is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. 2-Methoxy 17β-Estradiol binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule assembly and function.
Definition
ChEBI: A 17beta-hydroxy steroid, being 17beta-estradiol methoxylated at C-2.
Biological Activity
Apoptotic, antiproliferative and antiangiogenic agent, in vitro and in vivo ; acts via an estrogen receptor-independent mechanism. Induces p53-induced apoptosis via two pathways: activation of p38 and NF- κ B; and activation of JNK and AP-1 leading to Bcl-2 phosphorylation. Also upregulates death receptor 5 and binds to tubulin, inhibiting its assembly.
2-METHOXYESTRADIOL Preparation Products And Raw materials
Raw materials
Preparation Products
2-METHOXYESTRADIOL Suppliers
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View Lastest Price from 2-METHOXYESTRADIOL manufacturers
- Product
- 2-Methoxyestradiol 362-07-2
- Price
- US $20.00-10.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 20
- Release date
- 2024-03-20
- Product
- 2-Methoxyestradiol 362-07-2
- Price
- US $9.00-60.00/g
- Min. Order
- 10g
- Purity
- 99%
- Supply Ability
- 10 tons
- Release date
- 2024-03-22
- Product
- 2-Methoxyestradiol 362-07-2
- Price
- US $100.00/kg
- Min. Order
- 1kg
- Purity
- 99.9%
- Supply Ability
- 20tons
- Release date
- 2023-10-12